Name :
MLK3 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MLK3 Rabbit Polyclonal antibody. Positive WB detected in PC-3 cells, Jurkat cells. Positive IF detected in Hela cells. Positive IHC detected in human colon cancer tissue. Observed molecular weight by Western-blot: 60kd
Tested applications :
ELISA, WB, IHC, IF
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
MAP3K11 antibody; Mixed lineage kinase 3 antibody; MLK 3 antibody; MLK3 antibody; PTK1 antibody; SPRK antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of MLK3 recombinant protein (Accession Number: NM_002419). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200IF: 1:20-1:200
Background :
MLK3(Mixed lineage kinase 3) is also named as MAP3K11 and activates the JUN N-terminal pathway. It influences microtubule organization during the cell cycle. Mouse epididymal sperm contained an 60 kDa variant of MLK3, which may have been a result of proteolytic cleavage of the longer 93 kDa form seen in many tissues and the 50 kDa band is not known and not infrequently observed(PMID:17377140). Exposure of cells to LPS resulted in an increase in MLK3 dimers(of approximately 220 kDa), whereas inactivation of GSK-3b by TWS119 blocked MLK3 dimerization(PMID:21194439).
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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