Name :
MLK4 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MLK4 Rabbit Polyclonal antibody. Positive IHC detected in human brain tissue. Positive IF detected in C6 cells. Positive WB detected in HeLa cells. Observed molecular weight by Western-blot: 53 kDa
Tested applications :
ELISA, WB, IF, IHC
Species reactivity :
Human, Mouse, Rat; other species not tested.
Alternative names :
dJ862P8.3 antibody; KIAA1804 antibody; mixed lineage kinase 4 antibody; MLK4 antibody; RP5 862P8.2 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of MLK4 recombinant protein (Accession Number: NM_032435). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200IF: 1:10-1:100
Background :
MLK4 belongs to the MAP kinase kinase kinase subfamily. The MLK family members are characterized by the presence of signature sequences ofSer/Thr and Tyr kinases within their catalytic domain. The MLK1-4 contains an aminoterminal Src-Homology (SH3) domain, followed by the kinase domain, a leucine-zipper region, and a Cdc42/Rac-interactive binding (CRIB) motif. MLK4 expressed in two splicing variants, MLK4α and MLK4β. The difference of these two isoforms is located in their C-terminal portion. The negative effect of MLK4 on LPS-induced ERK and JNK activation could be very important in controlling the level of cytokine expression, and thus maintaining the balance of inflammatory responses.(PMID:21602844). This protein has 3 isoforms produced by alternative splicing with the molecular weight of 63 kDa, 113 kDa, 53 kDa.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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