Name :
MLXIPL antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MLXIPL Rabbit Polyclonal antibody. Positive WB detected in HepG2 cells, HeLa cells, human liver tissue. Positive IP detected in HepG2 cells. Observed molecular weight by Western-blot: 65 kDa
Tested applications :
ELISA, WB, IP
Species reactivity :
Human; other species not tested.
Alternative names :
bHLHd14 antibody; CHREBP antibody; MIO antibody; MLX interacting protein like antibody; MLX interactor antibody; MLXIPL antibody; MONDOB antibody; WBSCR14 antibody; WS bHLH antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of MLXIPL recombinant protein (Accession Number: BC012925). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:500-1:5000
Background :
Carbohydrate response element-binding protein (ChREBP), also known as MLXIPL, is a glucose-responsive transcription factor that has a fundamental role in the glucose-mediated induction of genes involved in hepatic glycolysis and lipogenesis. Circulating blood glucose levels affect ChREBP activity in hepatocytes largely by post-translational mechanisms that include phosphorylation-dependent subcellular localization [PMID:21665952]. It enhances expression of the liver pyruvate kinase (LPK) gene and all lipogenic enzyme genes resulting in the conversion of excess dietary carbohydrate into triglycerides that can be stored as fat [PMID:15118080]. Molecular Weight of ChREBP splice variants: 62/78/91/93 kDa.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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