Name :
MMP12 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MMP12 Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue, A549 cells. Positive IHC detected in human lung cancer tissue, human breast cancer tissue, human lung tissue. Positive IF detected in A549 cells. Observed molecular weight by Western-blot: 54 kDa,45 kDa
Tested applications :
ELISA, WB, IHC, IF
Species reactivity :
Human, Mouse; other species not tested.
Alternative names :
HME antibody; Macrophage elastase antibody; Macrophage metalloelastase antibody; Matrix metalloproteinase 12 antibody; MME antibody; MMP 12 antibody; MMP12 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of MMP12 recombinant protein (Accession Number: NM_002426). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200IF: 1:10-1:100
Background :
MMP12(Matrix metalloproteinase-12) is a 54 kDa proenzyme that is processed into a 45 kDa and then a 22 kDa active form(15723202). MMP9 and MMP12 promote intimal thickening by independent cleavage of N-cadherin, which elevates vascular smooth muscle cell proliferation via beta-catenin signalling. Its overexpression in myeloid lineage cells plays a key role in modulating myelopoiesis, immune suppression, and lung tumorigenesis(PMID: 21378275).
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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