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Name :
MMP19 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
MMP19 Rabbit Polyclonal antibody. Positive IHC detected in human liver cancer tissue. Positive IF detected in SH-SY5Y cells. Positive IP detected in human placenta tissue. Positive WB detected in SH-SY5Y cells, human placenta tissue. Observed molecular weight by Western-blot: 57-60 kDa

Tested applications :
ELISA, WB, IHC, IP, IF

Species reactivity :
Human,Mouse,Rat; other species not tested.

Alternative names :
matrix metallopeptidase 19 antibody; Matrix metalloproteinase 18 antibody; Matrix metalloproteinase 19 antibody; Matrix metalloproteinase RASI antibody; MMP 18 antibody; MMP 19 antibody; MMP18 antibody; MMP19 antibody; RASI antibody; RASI 1 antibody

Immunogen :
Human MMP19 Recombinant protein (GST tag)

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of MMP19 recombinant protein (Accession Number: NM_002429). Purification method: Antigen affinity purified.

Clonality :
Polyclonal

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:200-1:2000IHC: 1:20-1:200IF: 1:20-1:200

Background :
MMP19(matrix metalloproteinase-19) has the capacity to degrade several basement membrane proteins such as type IV collagen, laminin, tenascin C, and nidogen. It is expressed by microvascular endothelial cells in vitro as well as by capillaries in the inflamed synovial membrane, whereas its expression is absent in quiescent macrovascular endothelial cells of large arteries and veins . And it is also detected in capillaries of normal mammary tissue, benign mammary carcinomas and in skin capillaries(PMID:15241558).

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: Gardos- Channel