Name :
Anti-Carbonic Anhydrase VIII/CA8 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Rabbit monoclonal to Carbonic Anhydrase VIII/CA8
Tested applications :
WB, IP
Species reactivity :
Human Carbonic Anhydrase VIII / CA8
Alternative names :
AW546993 antibody; Ca8 antibody; CA8 antibody; CALS antibody; Cals antibody; Cals1 antibody; CAMRQ3 antibody; Car8 antibody; Carbonic Anhydrase VIII antibody; Carbonic Anhydrase VIII antibody; CARP antibody; Carp antibody; CA-VIII antibody; MGC120502 antibody; MGC99509 antibody; RP23-180H12.1 antibody; wdl antibody
Immunogen :
Human Carbonic Anhydrase VIII/CA8 (His Tag) recombinant protein
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained from a rabbit immunized with purified, recombinant Human Carbonic Anhydrase VIII / CA8 (rh Carbonic Anhydrase VIII / CA8; NP_004047.3; Met1-Gln290).
Clonality :
Monoclonal
Formulation :
0.2 μm filtered solution in PBS with 5% treha
Storage instructions :
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Applications :
WB: 20-50μg/mlIP: 1-4 μg/mg of lysate
Background :
The carbonic anhydrases (or carbonate dehydratases) are classified as metalloenzyme for its zinc ion prosthetic group and form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons, a reversible reaction that takes part in maintaining acid-base balance in blood and other tissues. The carbonic anhydrasekl (CA) family consists of at least 11 enzymatically active members and a few inactive homologous proteins. Carbonic anhydrase protein (CA) VIII, which is a member of the CA gene family, has been shown to have no catalytic CA activity and its biological function is still unknown. Increased expression of CA-RP VIII was observed in 78% of colorectal carcinomas. It suggested that CA-RP VIII plays a role in the process of invasion in colorectal cancer.
References :
Lehtonen J, et al. (2004) Characterization of CA XIII, a Novel Member of the Carbonic Anhydrase Isozyme Family. The Journal of Biological Chemistry. 279: 2719-27. Lindskog S. (1997) Structure and mechanism of carbonic anhydrase. Pharmacology & Therapeutics. 74(1)：1-20. Miyaji E, et al. (2003) Overexpression of carbonic anhydrase-related protein VIII in human colorectal cancer. The Journal of Pathology. 201(1): 37-45.
Related websites: https://www.medchemexpress.com/antibodies.html
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