Name :
MOG antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MOG Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue. Observed molecular weight by Western-blot: 28 kDa
Tested applications :
ELISA, WB
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
MOG antibody; MOGIG 2 antibody; myelin oligodendrOCyte glycoprotein antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of MOG recombinant protein (Accession Number: XM_005249131). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000
Background :
Myelin/oligodendrocyte glycoprotein (MOG), a 26-to 28-kDa glycoprotein, a myelin antigen at the outer surface of the central nervous system (CNS) myelin sheath, which may trigger T-cell as well as B-cell responses. It therefore constitutes a pivotal target for autoimmune responses, which result in inflammation and also demyelination in the CNS. Its presence on the outer- most lamellae of mature CNS myelin and its late appearance during myelinogenesis suggest that it contributes to myelin maturation or maintenance. 10 isoforms of MOG produced by alternative splicing have been described, and heterodimers may be formed between the different isoforms. Defects in MOG are the cause of narcolepsy type 7 (NRCLP7), a neurological disabling sleep disorder characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Role of MOG in the pathogenesis of multiple sclerosis (MS) has been reported but remains to be clarified.
References :
Cong H, Jiang Y, Tien P. Identification of the myelin oligodendrocyte glycoprotein as a cellular receptor for rubella virus. Journal of virology. 85(21):11038-47. 2011. Kuronen M, Hermansson M, Manninen O. Galactolipid deficiency in the early pathogenesis of neuronal ceroid lipofuscinosis model Cln8mnd : implications to delayed myelination and oligodendrocyte maturation. Neuropathology and applied neurobiology. 38(5):471-86. 2012.
Related websites: https://www.medchemexpress.com/antibodies.html
Popular product recommendations:
HRP-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L) medchemexpress
MiTF Rabbit mAb Technical Information
OPG Antibody: OPG Antibody is an unconjugated, approximately 43 kDa, rabbit-derived, anti-OPG polyclonal antibody. OPG Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, mouse, rat, and predicted: dog, cow background without labeling.
