Name :
MOV10 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MOV10 Rabbit Polyclonal antibody. Positive IP detected in HepG2 cells. Positive WB detected in HEK-293 cells, HeLa cells, HepG2 cells, human liver tissue, mouse liver tissue. Positive IF detected in HepG2 cells. Positive IHC detected in human prostate cancer tissue. Observed molecular weight by Western-blot: 110-115 kDa
Tested applications :
ELISA, WB, IHC, IP, IF
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
DKFZp667O1423 antibody; FLJ32791 antibody; fSAP113 antibody; gb110 antibody; KIAA1631 antibody; MOV10 antibody; Putative helicase MOV 10 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of MOV10 recombinant protein (Accession Number: NM_020963). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:200-1:2000IHC: 1:20-1:200IF: 1:10-1:100
Background :
MOV10, also named as KIAA1631, belongs to the DNA2/NAM7 helicase family and SDE3 subfamily. It is required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Human MOV10 may regulate a wide range of RNA viruses and could also control the retrotransposition of endogenous retroelements in mammals(PMID:22727223). MOV10 has a broad antiretroviral activity that can target a wide range of retroviruses, and it could be actively involved in host defense against retroviral infection. MOV10 can potently inhibit HIV-1 replication at multiple stages(PMID:20215113). It is involved in the progression of telomerase-catalyzing reaction via the interaction of telomerase protein and telomere DNA.
References :
Haussecker D, Cao D, Huang Y, Parameswaran P, Fire AZ, Kay MA. Capped small RNAs and MOV10 in human hepatitis delta virus replication. Nature structural & molecular biology. 15(7):714-21. 2008. Ma YX, Li D, Fu LJ. The role of Moloney leukemia virus 10 in hepatitis B virus expression in hepatoma cells. Virus research. 197:85-91. 2015. Johnson ME, Grassetti AV, Taroni JN. Stress granules and RNA processing bodies are novel autoantibody targets in systemic sclerosis. Arthritis research & therapy. 18(1):27. 2016. Han Y, Wang X, Dang Y, Zheng YH. APOBEC3G and APOBEC3F require an endogenous cofactor to block HIV-1 replication. PLoS pathogens. 4(7):e1000095. 2008. Cao D, Haussecker D, Huang Y, Kay MA. Combined proteomic-RNAi screen for host factors involved in human hepatitis delta virus replication. RNA (New York, N.Y.). 15(11):1971-9. 2009. Furtak V, Mulky A, Rawlings SA. Perturbation of the P-body component Mov10 inhibits HIV-1 infectivity. PloS one. 5(2):e9081. 2010. Banerjee S, Neveu P, Kosik KS. A coordinated local translational control point at the synapse involving relief from silencing and MOV10 degradation. Neuron. 64(6):871-84. 2009. Wang X, Han Y, Dang Y. Moloney leukemia virus 10 (MOV10) protein inhibits retrovirus replication. The Journal of biological chemistry. 285(19):14346-55. 2010.
Related websites: https://www.medchemexpress.com/antibodies.html
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