Name :
MPG antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MPG Rabbit Polyclonal antibody. Positive WB detected in HepG2 cells. Positive IHC detected in human prostate cancer. Observed molecular weight by Western-blot: 33kd
Tested applications :
ELISA, WB, IHC
Species reactivity :
human, mouse, rat; other species not tested.
Alternative names :
MPG antibody; PIG11 antibody; N methylpurine DNA glycosylase antibody; MDG antibody; 3 alkyladenine DNA glycosylase antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of MPG recombinant protein (Accession Number: NM_001015052). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200
Background :
N-methylpurine DNA glycosylase (MPG), an initiator glycosylase of the base excision repair (BER) pathway, typically repairs alkyl-induced DNA adducts, many of which are associated with genomic instability and tumorigenic risk [PMID:22801474] MPG initiates BER by removing TMZ-induced N3-methyladenine and N7-methylguanine base lesions, leaving abasic sites (AP sites) in DNA for further processing by BER [PMID:21377995]. MPG involves in modulating the genotoxic threshold response induced by the Sn2 alkylating agent ethyl methanesulfonate (EMS) [PMID:21071726].
References :
Yamamoto M, Yamamoto R, Takenaka S, Matsuyama S, Kubo K. Abundance of BER-related proteins depends on cell proliferation status and the presence of DNA polymerase β. Journal of radiation research. 56(4):607-14. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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