Name :
MPO antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MPO Mouse Monoclonal antibody. Positive WB detected in HL-60 cells. Positive IHC detected in human tonsillitis tissue, human liver tissue. Observed molecular weight by Western-blot: 90 kDa
Tested applications :
ELISA, WB, IHC
Species reactivity :
Human; other species not tested.
Alternative names :
MPO antibody; myeloperoxidase antibody
Immunogen :
Human MPO Recombinant protein (GST tag)
Isotype :
IgA
Preparation :
This antibody was obtained by immunization of MPO recombinant protein (Accession Number: NM_000250). Purification method: Protein A purified.
Clonality :
Monoclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200
Background :
The MPO gene encodes myeloperoxidase, a lysosomal hemoprotein located in the azurophilic granules of polymorphonuclear (PMN) leukocytes and monocytes. In response to stimulation, MPO is activated into a transient intermediate with potent antimicrobial oxidizing abilities(PMID:17650507). The mRNA is translated into a single protein of 90 kDa, which displays enzymatic activity and undergoes proteolytic maturation into a heavy chain of 59 kDa and a light chain of 13.5 kDa; these subunits then dimerize into the mature tetramer and the mature MPO is a heterotetramer composed of two identical heavy chains and two identical light chains(PMID:12773517). The 24-kDa material had a map identical to that of 13.5 kDa subunit and represents a dimer of the 13.5 kDa subunit (PMID:3008892). Defects in MPO are the cause of myeloperoxidase deficiency (MPOD). It has 3 isoforms produced by alternative splicing.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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