Name :
MPP5 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
MPP5 Rabbit Polyclonal antibody. Positive IP detected in mouse brain tissue. Positive WB detected in Y79 cells, human brain tissue. Observed molecular weight by Western-blot: 70-75kd
Tested applications :
ELISA, WB, IP
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
FLJ12615 antibody; MAGUK p55 subfamily member 5 antibody; MPP5 antibody; PALS1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of MPP5 recombinant protein (Accession Number: XM_047431691). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:500-1:5000
Background :
MPP5, also named as PALS1, belongs to the MAGUK family which interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. MPP5 is thought to organize intracellular PALS1-CRB-MUPP1 protein scaffolds in the retina that are involved in maintenance of photoreceptor–Mu¨ller glia cell adhesion. MPP5 plays a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells.
References :
Park B, Alves CH, Lundvig DM. PALS1 is essential for retinal pigment epithelium structure and neural retina stratification. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(47):17230-41. 2011. Alves CH, Sanz AS, Park B. Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene. Human molecular genetics. 22(1):35-50. 2013. Dudok JJ, Sanz AS, Lundvig DM, Wijnholds J. MPP3 is required for maintenance of the apical junctional complex, neuronal migration, and stratification in the developing cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(19):8518-27. 2013. Dudok JJ, Sanz AS, Lundvig DM. MPP3 regulates levels of PALS1 and adhesion between photoreceptors and Müller cells. Glia. 61(10):1629-44. 2013. Kanda A, Noda K, Yuki K. Atp6ap2/(pro)renin receptor interacts with Par3 as a cell polarity determinant required for laminar formation during retinal development in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(49):19341-51. 2013. Alves CH, Bossers K, Vos RM. Microarray and morphological analysis of early postnatal CRB2 mutant retinas on a pure C57BL/6J genetic background. PloS one. 8(12):e82532. 2013. Pellissier LP, Alves CH, Quinn PM. Targeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosis. PLoS genetics. 9(12):e1003976. 2013. Dudok JJ, Murtaza M, Henrique Alves C, Rashbass P, Wijnholds J. Crumbs 2 prevents cortical abnormalities in mouse dorsal telencephalon. Neuroscience research. 2016.
Related websites: https://www.medchemexpress.com/antibodies.html
Popular product recommendations:
Lipocalin 2 Antibody (YA992) medchemexpress
IL-1 beta Rabbit mAb custom synthesis
HBsAg Antibody: HBsAg Antibody is an unconjugated, approximately 44 kDa, goat-derived, anti-HBsAg polyclonal antibody. HBsAg Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, and predicted: Bee background without labeling.
