Product Name :
Corin
Description:
Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a Ki(inact) of 110 nM for LSD1 and an IC50 of 147 nM for HDAC1.
CAS:
1808113-09-8
Molecular Weight:
428.53
Formula:
C26H28N4O2
Chemical Name:
4-[3-(4-[(1S,2R)-2-aminocyclopropyl]phenylcarbamoyl)propyl]-N-(2-aminophenyl)benzamide
Smiles :
NC1=CC=CC=C1NC(=O)C1C=CC(CCCC(=O)NC2=CC=C(C=C2)[C@@H]2C[C@H]2N)=CC=1
InChiKey:
TYTLARZOLKJSJU-JTHBVZDNSA-N
InChi :
InChI=1S/C26H28N4O2/c27-22-5-1-2-6-24(22)30-26(32)19-10-8-17(9-11-19)4-3-7-25(31)29-20-14-12-18(13-15-20)21-16-23(21)28/h1-2,5-6,8-15,21,23H,3-4,7,16,27-28H2,(H,29,31)(H,30,32)/t21-,23+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a Ki(inact) of 110 nM for LSD1 and an IC50 of 147 nM for HDAC1.|Product information|CAS Number: 1808113-09-8|Molecular Weight: 428.53|Formula: C26H28N4O2|Chemical Name: 4-[3-(4-[(1S,2R)-2-aminocyclopropyl]phenylcarbamoyl)propyl]-N-(2-aminophenyl)benzamide|Smiles: NC1=CC=CC=C1NC(=O)C1C=CC(CCCC(=O)NC2=CC=C(C=C2)[C@@H]2C[C@H]2N)=CC=1|InChiKey: TYTLARZOLKJSJU-JTHBVZDNSA-N|InChi: InChI=1S/C26H28N4O2/c27-22-5-1-2-6-24(22)30-26(32)19-10-8-17(9-11-19)4-3-7-25(31)29-20-14-12-18(13-15-20)21-16-23(21)28/h1-2,5-6,8-15,21,23H,3-4,7,16,27-28H2,(H,29,31)(H,30,32)/t21-,23+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (233.Hydrochlorothiazide Cancer 36 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.LL-37 amide Inhibitor |Shelf Life: ≥12 months if stored properly.PMID:33159308 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Corin is able to inhibit the deacetylation of semisynthetic, reconstituted nucleosomes by the CoREST ternary complex. Corin shows irreversible inhibition of HDAC1 activity. In Comparison to MS-275, corin appears to more potently (Corin EC50 95 nM vs. MS-275 EC50 420 nM) and efficaciously induce cellular H3K9 acetylation. Interestingly, Corin (1 μM) is non-toxic to primary human melanocytes in contrast to MS-275 (1 μM).|References:|Kalin JH, et al. Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors. Nat Commun. 2018 Jan 4;9(1):53.Products are for research use only. Not for human use.|
