Product Name :
AZD-0284
Description:
AZD-0284 is a selective inverse agonist of the nuclear receptor RORγ. AZD-0284 has the potential for plaque psoriasis vulgaris and respiratory tract disorders treatment.
CAS:
2101291-07-8
Molecular Weight:
524.43
Formula:
C21H18F6N2O5S
Chemical Name:
(1R)-2-acetyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-5-methanesulfonyl-2,3-dihydro-1H-isoindole-1-carboxamide
Smiles :
CC(=O)N1CC2C=C(C=CC=2[C@@H]1C(=O)NC1C=CC(=CC=1)C(O)(C(F)(F)F)C(F)(F)F)S(C)(=O)=O
InChiKey:
QYYZXEPEVBXNNA-QGZVFWFLSA-N
InChi :
InChI=1S/C21H18F6N2O5S/c1-11(30)29-10-12-9-15(35(2,33)34)7-8-16(12)17(29)18(31)28-14-5-3-13(4-6-14)19(32,20(22,23)24)21(25,26)27/h3-9,17,32H,10H2,1-2H3,(H,28,31)/t17-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AZD-0284 is a selective inverse agonist of the nuclear receptor RORγ. AZD-0284 has the potential for plaque psoriasis vulgaris and respiratory tract disorders treatment.|Product information|CAS Number: 2101291-07-8|Molecular Weight: 524.43|Formula: C21H18F6N2O5S|Chemical Name: (1R)-2-acetyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-5-methanesulfonyl-2,3-dihydro-1H-isoindole-1-carboxamide|Smiles: CC(=O)N1CC2C=C(C=CC=2[C@@H]1C(=O)NC1C=CC(=CC=1)C(O)(C(F)(F)F)C(F)(F)F)S(C)(=O)=O|InChiKey: QYYZXEPEVBXNNA-QGZVFWFLSA-N|InChi: InChI=1S/C21H18F6N2O5S/c1-11(30)29-10-12-9-15(35(2,33)34)7-8-16(12)17(29)18(31)28-14-5-3-13(4-6-14)19(32,20(22,23)24)21(25,26)27/h3-9,17,32H,10H2,1-2H3,(H,28,31)/t17-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (190.CP-10 medchemexpress 68 mM; Need ultrasonic).Inclisiran medchemexpress |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:33183184 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|AZD0284 (0.37 μM; 5 days) inhibits IL-17A production in human TH17 cells. AZD0284 reduces polarization of TH17 into pathogenic TH17/1 cells. AZD0284 decreases frequency of single IL-17+cell as well as double positive TH17/1 cells. AZD0284 reduces IL-17A secretion and RNA expression of IL-17A, IL-17F, IL-22 and IL-23R.|Products are for research use only. Not for human use.|
