Eighted image (WI): field of view (FOV) 3006300 mm2, matrix 2886320, TR (repetition time)/TE (echodoi:10.1371/journal.pone.0053237.ttime) = 700/11 milliseconds (ms), 150u flip angle, and 3 mm slice thickness. The acquisition time was 3 minutes and 25 seconds. Axial T2WI: FOV 3006300 mm2, matrix 2726320, TR/ TE = 4000/87 ms, 140u flip angle, and 3 mm slice thickness. The acquisition time was 3 minutes and 54 seconds. Sagittal T2WI: FOV Mirin biological Microcystin-LR site activity 2506250 mm2, matrix 2726320, TR/ TE = 4000/87 ms, 140u flip angle, and 3 mm slice thickness. The acquisition time was 3 minutes and 54 seconds. Coronal T2WI: FOV 2506250 mm2, matrix 1926256, TR/ TE = 4000/104 ms, 145u flip angle, and 4 mm slice thickness. The acquisition time was 2 minutes and 26 seconds. CT was performed on a 16-row CT scanner (Brilliance 16, Philips Medical Systems). The imaging parameters are as follows: 120KV tube voltage, 250 mA tube current, and 3 mm thickness. Histopathologic examination. Each patient underwent transrectal ultrasound-guided sextant biopsies after completion of the MRI and CT examination within 10 days. The pathological results revealed that 23 patients had prostate cancer and 25331948 53 patients had benign prostatic hyperplasia. Imaging analysis. Two radiologists with 11 and 15 years’ diagnostic experience, respectively, blinded to the histopathologic results analyzed all images. Tumorous and non-neoplastic areas were determined on the MR images in patients with prostate cancer. They observed the hemorrhagic foci and calcification in the prostate and discussed the final results when disaccordance appeared. Statistical analysis. SPSS 17.0 statistical software was used to analyze data. Fisher’s exact test was used to analyze theSusceptibility Weighted Imaging in Prostate Cancerhemorrhagic manifestations on SWI between prostate cancer and benign prostatic hyperplasia group. A p value of less than 0.05 was considered significant. The sensitivity, specificity, accuracy, negative predictive values (NPV) and positive predictive values (PPV) at SWI and conventional MRI in detecting calcifications in prostate were evaluated using CT as the gold standard.ResultsThe tumor lesions of 19 patients with prostate cancer were located in the peripheral zone of the prostate, only 4 cases were within the central region. In 19 out of 23 patients (82.6 ) with prostate cancer, hemorrhage was detected within the tumorous areas (16 patients with prostate cancer in the peripheral zone and 3 patients with tumor lesions in the central zone) by SWI (Table 1). However, small hemorrhage was detected only in 1 patient out of 53 (1.9 ) patients with benign prostatic hyperplasia. Fisher’s exact test showed significant difference between prostate cancer and benign prostatic hyperplasia in the detection of hemorrhage within lesions (P,0.05). Out of the 19 patients with prostate cancer who had prostatic hemorrhage detected by SWI, only 7 patients had prostatic hemorrhage on conventional MRI (Figs. 1, 2, 3). Bleeding was not detected in all the patients by using CT. More importantly, the tumor lesions of 4 patients with prostate cancerwere located in the central zone of the prostate in this study, and tumor hemorrhage were detected in 3 patients by SWI. The calcificatinos were detected in 22 patients by CT, including 5 out of 23 patients with prostate cancer and 17 out of 53 patients with benign prostatic hyperplasia.When MRIs were used, the calcifications were detected in all the 22 patients by SWI whereas in.Eighted image (WI): field of view (FOV) 3006300 mm2, matrix 2886320, TR (repetition time)/TE (echodoi:10.1371/journal.pone.0053237.ttime) = 700/11 milliseconds (ms), 150u flip angle, and 3 mm slice thickness. The acquisition time was 3 minutes and 25 seconds. Axial T2WI: FOV 3006300 mm2, matrix 2726320, TR/ TE = 4000/87 ms, 140u flip angle, and 3 mm slice thickness. The acquisition time was 3 minutes and 54 seconds. Sagittal T2WI: FOV 2506250 mm2, matrix 2726320, TR/ TE = 4000/87 ms, 140u flip angle, and 3 mm slice thickness. The acquisition time was 3 minutes and 54 seconds. Coronal T2WI: FOV 2506250 mm2, matrix 1926256, TR/ TE = 4000/104 ms, 145u flip angle, and 4 mm slice thickness. The acquisition time was 2 minutes and 26 seconds. CT was performed on a 16-row CT scanner (Brilliance 16, Philips Medical Systems). The imaging parameters are as follows: 120KV tube voltage, 250 mA tube current, and 3 mm thickness. Histopathologic examination. Each patient underwent transrectal ultrasound-guided sextant biopsies after completion of the MRI and CT examination within 10 days. The pathological results revealed that 23 patients had prostate cancer and 25331948 53 patients had benign prostatic hyperplasia. Imaging analysis. Two radiologists with 11 and 15 years’ diagnostic experience, respectively, blinded to the histopathologic results analyzed all images. Tumorous and non-neoplastic areas were determined on the MR images in patients with prostate cancer. They observed the hemorrhagic foci and calcification in the prostate and discussed the final results when disaccordance appeared. Statistical analysis. SPSS 17.0 statistical software was used to analyze data. Fisher’s exact test was used to analyze theSusceptibility Weighted Imaging in Prostate Cancerhemorrhagic manifestations on SWI between prostate cancer and benign prostatic hyperplasia group. A p value of less than 0.05 was considered significant. The sensitivity, specificity, accuracy, negative predictive values (NPV) and positive predictive values (PPV) at SWI and conventional MRI in detecting calcifications in prostate were evaluated using CT as the gold standard.ResultsThe tumor lesions of 19 patients with prostate cancer were located in the peripheral zone of the prostate, only 4 cases were within the central region. In 19 out of 23 patients (82.6 ) with prostate cancer, hemorrhage was detected within the tumorous areas (16 patients with prostate cancer in the peripheral zone and 3 patients with tumor lesions in the central zone) by SWI (Table 1). However, small hemorrhage was detected only in 1 patient out of 53 (1.9 ) patients with benign prostatic hyperplasia. Fisher’s exact test showed significant difference between prostate cancer and benign prostatic hyperplasia in the detection of hemorrhage within lesions (P,0.05). Out of the 19 patients with prostate cancer who had prostatic hemorrhage detected by SWI, only 7 patients had prostatic hemorrhage on conventional MRI (Figs. 1, 2, 3). Bleeding was not detected in all the patients by using CT. More importantly, the tumor lesions of 4 patients with prostate cancerwere located in the central zone of the prostate in this study, and tumor hemorrhage were detected in 3 patients by SWI. The calcificatinos were detected in 22 patients by CT, including 5 out of 23 patients with prostate cancer and 17 out of 53 patients with benign prostatic hyperplasia.When MRIs were used, the calcifications were detected in all the 22 patients by SWI whereas in.
