Name :
GNRHR antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
GNRHR Rabbit Polyclonal antibody. Positive IP detected in MCF-7 cells. Positive WB detected in MCF7 cells, mouse ovary tissue, mouse testis tissue, PC-3 cells. Positive IHC detected in human testis tissue, human ovary tissue, mouse testis tissue. Positive FC detected in MCF-7 cells. Observed molecular weight by Western-blot: 38 kDa
Tested applications :
ELISA, WB, IHC, FC, IP
Species reactivity :
Human, Mouse; other species not tested.
Alternative names :
GnRH R antibody; GnRH receptor antibody; GNRHR antibody; GNRHR1 antibody; GRHR antibody; LHRHR antibody; LRHR antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of Peptide (Accession Number: NM_000406). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:200-1:2000IHC: 1:20-1:200
Background :
GNRHR, also named as GRHR, belongs to the G-protein coupled receptor 1 family. GNRHR is a receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). It mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform2 of GNRHR may act as an inhibitor of GnRH-R signaling. Defects in GNRHR are a cause of idiopathic hypogonadotropic hypogonadism (IHH). Defects in GNRHR are a cause of fertile eunuch syndrome. The antibody only recognizes the isoform1 of GNRHR. The predicted unmodified molecular weight of the human GNRHR is ~38 kDa, the larger band (50-60 kDa) is likely to represent a glycosylated form of GNRHR.
References :
Torrealday S, Lalioti MD, Guzeloglu-Kayisli O, Seli E. Characterization of the gonadotropin releasing hormone receptor (GnRHR) expression and activity in the female mouse ovary. Endocrinology. 154(10):3877-87. 2013. Karampelas T, Argyros O, Sayyad N. GnRH-Gemcitabine conjugates for the treatment of androgen-independent prostate cancer: pharmacokinetic enhancements combined with targeted drug delivery. Bioconjugate chemistry. 25(4):813-23. 2014.
Related websites: https://www.medchemexpress.com/antibodies.html
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