Name :
GPR143 Polyclonal Antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Polyclonal antibody to GPR143
Tested applications :
WB
Species reactivity :
Human, Mouse, Rat
Alternative names :
GPR143 antibody; NYS6 antibody; OA1 antibody; G-protein coupled receptor 143 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 314-404 of human GPR143 (NP_000264.2).
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage instructions :
Store at -20℃. Avoid freeze / thaw cycles.
Applications :
WB 1:1000 – 1:2000
Background :
Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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