Name :
GPX7 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
GPX7 Rabbit Polyclonal antibody. Positive WB detected in human liver tissue, human brain tissue, Transfected HEK-293 cells. Positive IHC detected in human liver cancer tissue, human brain tissue. Observed molecular weight by Western-blot: 21 kDa
Tested applications :
ELISA, WB, IHC
Species reactivity :
Human; other species not tested.
Alternative names :
CL683 antibody; FLJ14777 antibody; glutathione peroxidase 7 antibody; GPx 7 antibody; GPX6 antibody; GPX7 antibody; GSHPx 7 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of GPX7 recombinant protein (Accession Number: NM_015696). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200
Background :
GPX7(Glutathione peroxidase 7) is also named as GPX6,CL683,GSHPx-7 and belongs to the glutathione peroxidase family.It shares approximately 45% amino acid sequence with other GPX family members.Because GPX7 expression protected cells from acidic bile acidinduced DNA damage, it may protect oesophageal epithelial cells from acidic bile acid-induced apoptosis(PMID:22157330).
References :
Peng DF, Hu TL, Soutto M, Belkhiri A, El-Rifai W. Loss of glutathione peroxidase 7 promotes TNF-α-induced NF-κB activation in Barrett’s carcinogenesis. Carcinogenesis. 35(7):1620-8. 2014. Peng DF, Hu TL, Soutto M, Belkhiri A, El-Rifai W. Glutathione Peroxidase 7 Suppresses Bile Salt-Induced Expression of Pro-Inflammatory Cytokines in Barrett’s Carcinogenesis. Journal of Cancer. 5(7):510-7. 2014. Peng D, Belkhiri A, Hu T. Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells. Gut. 61(9):1250-60. 2012. Peng D, Hu T, Soutto M, Belkhiri A, Zaika A, El-Rifai W. Glutathione peroxidase 7 has potential tumour suppressor functions that are silenced by location-specific methylation in oesophageal adenocarcinoma. Gut. 63(4):540-51. 2014. Chang YC, Yu YH, Shew JY. Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human. EMBO molecular medicine. 5(8):1165-79. 2013. Ramming T, Hansen HG, Nagata K, Ellgaard L, Appenzeller-Herzog C. GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum. Free radical biology & medicine. 70:106-16. 2014.
Related websites: https://www.medchemexpress.com/antibodies.html
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