Name :
GRB10 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
GRB10 Rabbit Polyclonal antibody. Positive IHC detected in human liver tissue, human kidney tissue. Positive IF detected in HepG2 cells. Positive WB detected in mouse liver tissue, HeLa cells, HepG2 cells, mouse brain tissue, rat brain tissue. Observed molecular weight by Western-blot: 60-70 kDa
Tested applications :
ELISA, WB, IF, IHC
Species reactivity :
Human, Mouse, Rat; other species not tested.
Alternative names :
Grb 10 antibody; GRB IR antibody; GRB10 antibody; GRB10 adapter protein antibody; GRBIR antibody; IRBP antibody; KIAA0207 antibody; MEG1 antibody; RSS antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of GRB10 recombinant protein (Accession Number: XM_017012064). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200IF: 1:20-1:200
Background :
Growth factor receptor-bound protein 10 (GRB10) is an adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. GRB10 has three consensus domains including pleckstrin homology (PH) domain, SH2/SH3 domain and Ras-associating domain. By binding to kinases, GRB10 suppresses signals from activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. It may play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation.
References :
Xia HF, Cao JL, Jin XH, Ma X. MiR199a is implicated in embryo implantation by regulating Grb10 in rat. Reproduction (Cambridge, England). 147(1):91-9. 2014. Park Y, Jin HS, Lopez J. TSC1 regulates the balance between effector and regulatory T cells. The Journal of clinical investigation. 123(12):5165-78. 2013.
Related websites: https://www.medchemexpress.com/antibodies.html
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