Name :
H6PD antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
H6PD Rabbit Polyclonal antibody. Positive IP detected in HepG2 cells. Positive WB detected in HepG2 cells, HeLa cells, mouse liver tissue. Positive IHC detected in human hepat℃irrhosis tissue, human liver cancer tissue. Observed molecular weight by Western-blot: 89-95 kDa
Tested applications :
ELISA, IHC, WB, IP
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
6PGL antibody; DKFZp686A01246 antibody; G6PDH antibody; GDH antibody; H6PD antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of H6PD recombinant protein (Accession Number: XM_017002865). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:500-1:5000IHC: 1:20-1:200
Background :
Hexose-6-phosphate dehydrogenase (H6PD) is also named as GDH,6PGL. It is the main NADPH generating enzyme in the lumen of the endoplasmic reticulum. H6PD is regarded as an ancillary enzyme in prereceptorial glucocorticoid activation and probably acts as a nutrient sensor and as a prosurvival factor(PMID:21620971). H6PD has been shown to be a glycoprotein and tissue differences in glycosylation status might explain both the difference in migration on SDS-PAGE gels as well as in activity. Defects in H6PD are a cause of cortisone reductase deficiency (CRD). This antibody is specific to H6PD.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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