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Name :
HIST2H2AA4 Polyclonal Antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
Polyclonal antibody to HIST2H2AA4

Tested applications :
WB

Species reactivity :
Human

Alternative names :
HIST2H2AA4 antibody; H2A/R antibody; histone H2A type 2-A antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
Antigen: A synthetic Peptide of human HIST2H2AA4

Clonality :
Polyclonal

Formulation :
PBS with 0.02% sodium azide, pH7.3.

Storage instructions :
Store at 4℃. Avoid freeze / thaw cycles.

Applications :
WB 1:500 – 1:1000

Background :
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: Gardos- Channel