Name :
HLX antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
HLX Rabbit Polyclonal antibody. Positive IHC detected in human endometrial cancer tissue. Positive WB detected in human placenta tissue. Observed molecular weight by Western-blot: 50 kDa
Tested applications :
ELISA, WB, IHC
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
H2.0 like homeobox antibody; H2.0 like homeobox protein antibody; HB24 antibody; HLX antibody; HLX1 antibody; Homeobox protein HB24 antibody; Homeobox protein HLX1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of HLX recombinant protein (Accession Number: NM_021958). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200
Background :
In immune system, Hlx is a Th1-special transcription factor that interacts specifically with T-bet, and synergistically they promote IFN-γ expression when co-expressed. It can down-regulate the IL-4 receptor expression in naive CD4+ T cells [PMID:14688316]. Over expression of Hlx contributes ot the aberrant expression of IFN-γ in normal CD4+ T cells during the differentiation under Th2-polarizing conditions. In addition, Hlx is a negative regulator of IFN-γ production in NK cells and its inhibitory function is achieved at least in part through the proteasomal degradation of STAT4 [PMID:16424184].
References :
Liu T, Chen J, Xiao S, Lei X. H2.0-like homeobox 1 acts as a tumor suppressor in hepatocellular carcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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