Name :
HRPT2 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
HRPT2 Rabbit Polyclonal antibody. Positive IHC detected in human breast cancer tissue. Positive IF detected in Hela cells. Positive IP detected in mouse testis tissue. Positive WB detected in human lung tissue, human heart tissue, mouse testis tissue. Observed molecular weight by Western-blot: 61 kDa
Tested applications :
ELISA, WB, IHC, IF, IP
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
C1orf28 antibody; CDC73 antibody; FLJ23316 antibody; HPT JT antibody; HRPT2 antibody; Hyperparathyroidism 2 protein antibody; Parafibromin antibody
Immunogen :
Human HRPT2; CDC73 Recombinant protein (GST tag)
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of HRPT2 recombinant protein (Accession Number: BC014351). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:200-1:2000IHC: 1:20-1:200IF: 1:20-1:200
Background :
Parafibromin is a product of the hyperparathyroidism-jaw tumor syndrome gene HRPT2/CDC73, a putative tumor suppressor gene recently implicated in the autosomal dominant hyperparathyroidism-jaw tumor familial cancer syndrome, sporadic parathyroid cancer, and a minority of families with isolated hyperparathyroidism (PMID: 15580289). Defects in CDC73 are causes of hyperparathyroidism type 1 (HRPT1) and hyperparathyroidism type 2 (HRPT2) as well as parathyroid carcinoma (PRTC) (PMID: 12434154). Tumor suppressor parafibromin to the transcription elongation and RNA processing pathway as a PAF1 complex- and RNA polymerase II-bound protein (PMID: 15923622). Besides, parafibromin is also involved in post-transcriptional control pathways (PMID: 16116486). Recent report has revealed that pathogenic mutation, such as CDC73 gene mutation, is able to affect histone monoubiquitination (PMID: 22021426).
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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