Name :
HRSP12 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
HRSP12 Rabbit Polyclonal antibody. Positive WB detected in human liver tissue. Positive IHC detected in human liver cancer tissue. Observed molecular weight by Western-blot: 14.5kd
Tested applications :
ELISA, WB, IHC
Species reactivity :
Human, Rat; other species not tested.
Alternative names :
heat responsive protein 12 antibody; HRSP12 antibody; P14.5 antibody; PSP antibody; Ribonuclease UK114 antibody; UK114 antibody; UK114 antigen homolog antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of HRSP12 recombinant protein (Accession Number: NM_005836). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200
Background :
Ribonuclease UK114, also named HRSP12, is found predominantly in human adult kidney and liver and is responsible for inhibiting translation by cleaving mRNA. UK114 is mostly expressed in cytoplasm, but occasionally in nucleus in less differentiated cells. UK114 cleaves phosphodiester bonds only in single-stranded RNA. The levels of both the mRNA and protein are markedly reduced in heptatocellular tumors and in human hepatoma cell lines compared with normal liver tissues, suggesting that ribonuclease UK114 may be an important biomarker for heptatic carcinoma. Current antibody catalog# 12930-1-AP is a rabbit polyclonal antibody raised from human full-length UK114.
References :
Dhawan L, Liu B, Pytlak A, Kulshrestha S, Blaxall BC, Taubman MB. Y-box binding protein 1 and RNase UK114 mediate monocyte chemoattractant protein 1 mRNA stability in vascular smooth muscle cells. Molecular and cellular biology. 32(18):3768-75. 2012.
Related websites: https://www.medchemexpress.com/antibodies.html
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