Name :
HSD3B2 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
HSD3B2 Rabbit Polyclonal antibody. Positive WB detected in human adrenal gland tissue. Positive IHC detected in human testis tissue. Observed molecular weight by Western-blot: 42kd
Tested applications :
ELISA, WB, IHC
Species reactivity :
Human; other species not tested.
Alternative names :
3b HSD antibody; HSD3B2 antibody; HSDB antibody; HSDB3 antibody; HSDB3B antibody; SDR11E2 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of HSD3B2 recombinant protein (Accession Number: NM_001166120). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:1000-1:10000IHC: 1:20-1:200
Background :
HSD3B2(3-beta-hydroxy-Delta(5)-steroid dehydrogenase) belongs to the 3-beta-HSD family and catalyzes the oxidation and isomerization of delta-5-3-beta-hydroxysteroid precursors into delta-4-ketosteroids, thus leading to the formation of all classes of steroid hormones.HSD3B2 is expressed almost exclusively in adrenals and gonads, whereas HSD3B1 is expressed predominantly in placenta and skin(PMID:1682237). Defects in HSD3B2 are the cause of adrenal hyperplasia type 2 (AH2).
References :
Dominguez MA, Cho N, Zhang B, Neal MS, Foster WG. Brain-derived neurotrophic factor expression in granulosa lutein cells. Reproductive biomedicine online. 22(1):17-24. 2011. Tong A, Jia A, Yan S, Zhang Y, Xie Y, Liu G. Ectopic cortisol-producing adrenocortical adenoma in the renal hilum: histopathological features and steroidogenic enzyme profile. International journal of clinical and experimental pathology. 7(7):4415-21. 2014. Lee BH, Indran IR, Tan HM. A Dietary Medium-Chain Fatty Acid, Decanoic Acid, Inhibits Recruitment of Nur77 to the HSD3B2 Promoter In Vitro and Reverses Endocrine and Metabolic Abnormalities in a Rat Model of Polycystic Ovary Syndrome. Endocrinology. 157(1):382-94. 2016.
Related websites: https://www.medchemexpress.com/antibodies.html
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