Name :
HSF4 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
HSF4 Rabbit Polyclonal antibody. Positive WB detected in human heart tissue, human skeletal muscle tissue, mouse skeletal muscle tissue. Observed molecular weight by Western-blot: 53-58kd
Tested applications :
ELISA, WB
Species reactivity :
human, mouse; other species not tested.
Alternative names :
HSF4 antibody; HSTF 4 antibody; hHSF4 antibody; Heat shOCk factor protein 4 antibody; CTM antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of Peptide (Accession Number: BC130383). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000
Background :
HSF4 belongs to the HSF family. HSF4 is a DNA-binding protein that specifically binds heat shock promoter elements (HSE). The isoform HSF4A represses transcription while the isoform HSF4B activates transcription. HSF4 is a homotrimer which exhibits constitutive DNA binding and forms trimers even in the absence of stress. It is expressed in heart, skeletal muscle, eye and brain, and at much lower levels in some other tissues. Mutation of HSF4 will cause lamellar cataract which is known as Marner type cataract (CAM). Lamellar cataract is an autosomal dominant common type of infantile cataract. Finger malformation is observed in some kindreds. Inheritance of these forms of cataract is autosomal dominant.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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