Name :
Anti-BIN1 Rabbit antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
BIN1 Rabbit polyclonal antibody
Tested applications :
WB, IHC-P, ICC/IF, FC
Species reactivity :
Human, Mouse, Rat
Alternative names :
CNM2; AMPH2; AMPHL; SH3P9 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
Antigen: Recombinant protein of human BIN1
Clonality :
Polyclonal
Formulation :
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage instructions :
Store at -20°C. Stable for 12 months from date of receipt.
Applications :
WB: 1/1000IHC: 1/20ICC/IF: 1/20FC: 1/20
Background :
Swiss-Prot Acc.O00499.Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653). Is a negative regulator of endocytosis . Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates . May be involved in the regulation of MYC activity and the control cell proliferation (PubMed:8782822). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed:28893863).
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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