Name :
IFITM1 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
IFITM1 Rabbit Polyclonal antibody. Positive WB detected in K-562 cells, HepG2 cells. Positive IP detected in ROS1728 cells. Positive IHC detected in human lymphoma tissue, human lung cancer tissue. Observed molecular weight by Western-blot: 17-19kd
Tested applications :
ELISA, WB, IHC, IP
Species reactivity :
Human; other species not tested.
Alternative names :
9 27 antibody; CD225 antibody; IFI17 antibody; IFITM1 antibody; Interferon induced protein 17 antibody; Leu 13 antigen antibody; LEU13 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of IFITM1 recombinant protein (Accession Number: NM_003641). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:200-1:2000IHC: 1:20-1:200
Background :
IFITM1(interferon induced transmembrane protein), also named DSPA2a or interferon-induced protein 17 (IFI17), belongs to the CD225 family. It has two transmembrane domain and serves as an IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, influenza A H1N1 virus, West Nile virus (WNV), and dengue virus , by inhibiting the early steps of replication. IFITM proteins are recently identified as viral restriction factors that inhibit infection mediated by the influenza A virus (IAV) hemagglutinin (HA) protein. Also they serve as important components of the innate immune system to restrict HIV-1 infection.
References :
Lu J, Pan Q, Rong L, He W, Liu SL, Liang C. The IFITM proteins inhibit HIV-1 infection. Journal of virology. 85(5):2126-37. 2011. Grow EJ, Flynn RA, Chavez SL. Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells. Nature. 522(7555):221-5. 2015. Wrensch F, Karsten CB, Gnirß K. Interferon-Induced Transmembrane Protein-Mediated Inhibition of Host Cell Entry of Ebolaviruses. The Journal of infectious diseases. 212 Suppl 2:S210-8. 2015. Khodarev N, Ahmad R, Rajabi H. Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer. Oncogene. 29(6):920-9. 2010. Li K, Markosyan RM, Zheng YM. IFITM proteins restrict viral membrane hemifusion. PLoS pathogens. 9(1):e1003124. 2013. Bertram S, Dijkman R, Habjan M. TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium. Journal of virology. 87(11):6150-60. 2013. Mudhasani R, Tran JP, Retterer C. IFITM-2 and IFITM-3 but not IFITM-1 restrict Rift Valley fever virus. Journal of virology. 87(15):8451-64. 2013. Li J, Liu K, Liu Y. Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity. Nature immunology. 14(8):793-803. 2013.
Related websites: https://www.medchemexpress.com/antibodies.html
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