Name :
Anti-BMP-2 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Mouse monoclonal to BMP-2
Tested applications :
IF, ICC/IF
Species reactivity :
Human BMP-2
Alternative names :
BDA2A antibody; BMP2 antibody; RP23-384M14.3 antibody; AI467020a antibody; Bmp2 antibody; BDA2 antibody; BMP2A antibody; Bmp2a antibody; AI467020 antibody
Immunogen :
Human BMP-2 recombinant protein
Isotype :
Mouse IgG1
Preparation :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human BMP-2 (rh BMP-2; NP_001191.1; Gln283-Arg396). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Clonality :
Monoclonal
Formulation :
0.2 μm filtered solution in PBS with 5% trehalose
Storage instructions :
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Applications :
ICC/IF: 10-25 μg/mL
Background :
BMP-2 protein, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. BMP-2 protein is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokine receptor interaction. BMP-2 and BMP-7 are osteogenic BMPs that have been demonstrated to potently induce osteoblast differentiation in a variety of cell types. BMP-2, BMP-4 and BMP-7 are known to be of major importance in bone formation and repair. In cancerous tissues BMP-2 protein may play an important role in the progression of glioma.
References :
Jiao X, et al. (2007) Heparan sulfate proteoglycans (HSPGs) modulate BMP-2 osteogenic bioactivity in C2C12 cells. J Biol Chem. 282(2):1080-6. Michon F, et al. (2008) BMP-2 and BMP-7 play antagonistic roles in feather induction. Development 135 (16):2797-805.
Related websites: https://www.medchemexpress.com/antibodies.html
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