Name :
IGF1R-Specific antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
IGF1R-Specific Mouse Monoclonal antibody. Positive WB detected in HepG2 cells, HeLa cells, HUVEC cells, MCF-7 cells. Positive IHC detected in human breast cancer tissue. Observed molecular weight by Western-blot: 130-140 kDa
Tested applications :
ELISA, WB, IHC
Species reactivity :
Human; other species not tested.
Alternative names :
CD221 antibody; IGF I receptor antibody; IGF1R antibody; IGF1R-Specific antibody; IGFIR antibody; IGFR antibody; JTK13 antibody
Immunogen :
Isotype :
Mouse IgG1
Preparation :
This antibody was obtained by immunization of Peptide (Accession Number: NM_000875). Purification method: Protein G purified.
Clonality :
Monoclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:1000-1:10000IHC: 1:50-1:500
Background :
IGF1R, also named as CD221, belongs to the protein kinase superfamily, Tyr protein kinase family and Insulin receptor subfamily. IGF1R binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, IGF1R binds IGF1. The hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, the hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. Defects in IGF1R may be a cause in some cases of resistance to insulin-like growth factor 1 (IGF1 resistance).
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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