Name :
IGFBP1 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
IGFBP1 Rabbit Polyclonal antibody. Positive IHC detected in human placenta tissue, human stomach tissue. Positive WB detected in human placenta tissue. Observed molecular weight by Western-blot: 35 kDa
Tested applications :
ELISA, WB, IHC
Species reactivity :
Human; other species not tested.
Alternative names :
AFBP antibody; hIGFBP 1 antibody; IBP 1 antibody; IBP1 antibody; IGF binding protein 1 antibody; IGF BP25 antibody; IGFBP 1 antibody; IGFBP1 antibody; Placental protein 12 antibody; PP12 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of IGFBP1 recombinant protein (Accession Number: NM_000596). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:1000IHC: 1:20-1:200
Background :
Insulin-like growth factor (IGF)-binding proteins (IGFBPs) family contains members like IGFBP-1, -2, -3, -4,-5 and-6. IGFBPs prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. IGF-I physically interacts with IGFBP-1 and that IGFBP-1 also binds to an integrin receptor, but the effect of IGFBP-1 on cell migration may be independent of IGF-I and is probably mediated through the alpha 5 beta 1 integrin. Transgenic mice models demonstrated that IGFBPs played important roles in the pathogenesis of obesity and insulin resistance. Studies conducted in humans demonstrated the close relation between IGFBPs and the components of the metabolic syndrome.
References :
Lai G, Zhang Y, Wang L. Differences in IGF axis-related proteins in amniotic fluid of trisomy 21 and trisomy 18 using a multiple reaction monitoring approach. Prenatal diagnosis. 34(12):1146-52. 2014. Feng T, Qiao G, Feng L. Stathmin is key in reversion of doxorubicin resistance by arsenic trioxide in osteosarcoma cells. Molecular medicine reports. 10(6):2985-92. 2014.
Related websites: https://www.medchemexpress.com/antibodies.html
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