Name :
IL12B antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
IL12B Mouse Monoclonal antibody. Positive WB detected in human liver tissue. Observed molecular weight by Western-blot: 37 kDa
Tested applications :
ELISA, WB
Species reactivity :
Human, Pig; other species not tested.
Alternative names :
CLMF antibody; CLMF p40 antibody; CLMF2 antibody; IL 12 subunit p40 antibody; IL 12B antibody; IL12B antibody; Interleukin 12 subunit beta antibody; NKSF antibody; NKSF2 antibody
Immunogen :
Isotype :
Mouse IgG2a
Preparation :
This antibody was obtained by immunization of IL12B recombinant protein (Accession Number: NM_002187). Purification method: Protein A purified.
Clonality :
Monoclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000
Background :
Interleukin-12 (IL-12), is a cytokine that is secreted by activated phagocytes and dendritic cells and that induces interferon-γproduction by natural-killer and T lymphocytes. IL-12 is a 75 kDa heterodimer composed of a 35 kDa subunit (IL-12A p35) and a 40 kDa subunit (IL-12B p40) that is secreted by a wide variety of antigen presenting cells (APCs), including phagocytes, B cells and Langerhans cells. IL-12B has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of IL-12B was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of IL-12B has been reported to be associated with the severity of atopic and non-atopic asthma in children.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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