Name :
IL15RA antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
IL15RA Rabbit Polyclonal antibody. Positive IHC detected in human liver tissue, human brain tissue, human heart tissue, human kidney tissue, human skin tissue, human spleen tissue, human testis tissue. Positive WB detected in HeLa cells. Observed molecular weight by Western-blot: 55-65 kDa
Tested applications :
ELISA, WB, IHC
Species reactivity :
Human; other species not tested.
Alternative names :
IL 15 receptor subunit alpha antibody; IL 15R alpha antibody; IL 15RA antibody; IL15RA antibody; interleukin 15 receptor antibody; alpha antibody; sIL 15 receptor subunit alpha antibody; sIL 15R alpha antibody; sIL 15RA antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of IL15RA recombinant protein (Accession Number: NM_001243539). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200
Background :
Interleukin-15 (IL-15) is a pleiotropic cytokine that plays an important role in both innate and adaptive immunity. IL-15 is mainly produced by activated monocytes, macrophages and dendritic cells, and is structurally similar to IL-2 (PMID: 8178155; 12401478). These two cytokines share the same IL-2/15Rβ and common γ-chain receptor subunits. In addition, IL-2 and IL-15 have their own private α-chain receptor subunit, IL-2Rα and IL-15Rα, respectively (PMID: 7641685). The IL-15Rα chain is expressed by many cell types including monocytes, DCs, NK, T cells and fibroblasts. Several isoforms of IL-15Rα exist and are generated either by alternative splicing or by proteolytic cleavage (PMID: 10480910; 15265897).
References :
Perrier C, Arijs I, Staelens D. Interleukin-15 receptor α expression in inflammatory bowel disease patients before and after normalization of inflammation with infliximab. Immunology. 138(1):47-56. 2013.
Related websites: https://www.medchemexpress.com/antibodies.html
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