Name :
Anti-BNIP3 Rabbit antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
BNIP3 Rabbit polyclonal antibody
Tested applications :
WB, ICC/IF
Species reactivity :
Human, Mouse, Rat
Alternative names :
Immunogen :
Isotype :
Rabbit IgG
Preparation :
Antigen: A synthetic peptide of human BNIP3
Clonality :
Polyclonal
Formulation :
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage instructions :
Store at -20°C. Stable for 12 months from date of receipt.
Applications :
WB: 1/1000ICC/IF: 1/50
Background :
Swiss-Prot Acc.Q12983.Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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