Name :
IL6R antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
IL6R Rabbit Polyclonal antibody. Positive WB detected in mouse spleen tissue. Positive IP detected in mouse spleen tissue. Observed molecular weight by Western-blot: 80 kDa
Tested applications :
ELISA, WB, IP
Species reactivity :
Human, Mouse; other species not tested.
Alternative names :
CD126 antibody; gp80 antibody; IL 6 receptor subunit alpha antibody; IL 6R 1 antibody; IL 6R alpha antibody; IL 6R subunit alpha antibody; IL 6RA antibody; IL-6 R alpha antibody; IL6R antibody; IL6RA antibody; interleukin 6 receptor antibody; Membrane glycoprotein 80 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of IL6R recombinant protein (Accession Number: NM_000565). Purification method: Antigen Affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:200-1:2000
Background :
Interleukin-6 (IL-6) is a pleiotropic cytokine produced by a variety of cells during infection, trauma, and immunological challenge (PMID: 8274730). IL-6 acts via a receptor complex consisting of two distinct membrane-bound glycoproteins, an 80-kDa IL-6-binding subunit (IL-6R, CD126, gp80) and a 130-kDa signal-transducing element (gp130, CD130). After binding of IL-6 to membrane-bound IL-6R, the complex of IL-6 and IL-6R associates with gp130, thus activating the receptor (PMID: 9716487). Expression of gp130 is found in almost all organs while expression of IL-6R is predominantly confined to hepatocytes and leukocyte subpopulations (monocytes, neutrophils, T cells, and B cells) (PMID: 11149892). Soluble form of IL-6R has been found in human serum and urine (PMID: 2529343; 1545125).
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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