Name :
ING3 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
ING3 Rabbit Polyclonal antibody. Positive IHC detected in human breast cancer tissue. Positive WB detected in mouse uterus tissue, HepG2 cells. Observed molecular weight by Western-blot: 47 kDa
Tested applications :
ELISA, IHC, WB
Species reactivity :
Human, Mouse; other species not tested.
Alternative names :
Eaf4 antibody; FLJ20089 antibody; ING2 antibody; ING3 antibody; Inhibitor of growth protein 3 antibody; p47ING3 antibody
Immunogen :
Human ING3 Recombinant protein (GST tag)
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of ING3 recombinant protein (Accession Number: NM_198267). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200
Background :
Members of inhibitor of growth (ING) family function in inhibiting cell growth and inducing apoptosis. They are sequence homologous proteins. ING3 can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. This antibody is specifically against p47ING3.
References :
Chen G, Wang Y, Garate M, Zhou J, Li G. The tumor suppressor ING3 is degraded by SCF(Skp2)-mediated ubiquitin-proteasome system. Oncogene. 29(10):1498-508. 2010. Jin L, Li D, Lee JS. p90 RSK2 mediates antianoikis signals by both transcription-dependent and -independent mechanisms. Molecular and cellular biology. 33(13):2574-85. 2013. Gou WF, Sun HZ, Zhao S. Downregulated inhibitor of growth 3 (ING3) expression during colorectal carcinogenesis. The Indian journal of medical research. 139(4):561-7. 2014. Yu G, Lee YC, Cheng CJ. RSK promotes prostate cancer progression in bone through ING3, CKAP2, and PTK6-mediated cell survival. Molecular cancer research : MCR. 13(2):348-57. 2015. Wang Y, Dai DL, Martinka M, Li G. Prognostic significance of nuclear ING3 expression in human cutaneous melanoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 13(14):4111-6. 2007.
Related websites: https://www.medchemexpress.com/antibodies.html
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