Name :
INPP5J antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
INPP5J Rabbit Polyclonal antibody. Positive WB detected in human heart tissue, mouse lung tissue. Positive IP detected in mouse lung tissue. Positive IHC detected in human kidney tissue, human heart tissue. Observed molecular weight by Western-blot: 107 kDa,70 kDa
Tested applications :
ELISA, WB, IHC, IP
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
INPP5 antibody; INPP5J antibody; PIB5PA antibody; PIPP antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of INPP5J recombinant protein (Accession Number: NM_001284289). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:200-1:2000IHC: 1:20-1:200
Background :
INPP5J(Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A) is also named as PIB5PA, PIPP and belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family. INPP5J is a key signalling molecule that regulates dendritic outgrowth through activation of small GTPase signalling via interaction between FRMPD4 and ARHGEF7. It can control the resting membrane potential through a specific ion-channel-receptor-ligand interaction that brings about a large conformational change, analogous to neurotransmitter activation of ion channels at synapses. (PMID:22595022). This protein has 3 isoforms produced by alternative splicing.
References :
Lin C, Liu A, Zhu J. miR-508 sustains phosphoinositide signalling and promotes aggressive phenotype of oesophageal squamous cell carcinoma. Nature communications. 5:4620. 2014. Zhu T, Yuan J, Wang Y, Gong C, Xie Y, Li H. MiR-661 contributed to cell proliferation of human ovarian cancer cells by repressing INPP5J expression. Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie. 75:123-8. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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