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Name :
INSIG1 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
INSIG1 Rabbit Polyclonal antibody. Positive IHC detected in human liver tissue, human kidney tissue. Positive IF detected in MCF-7 cells. Positive WB detected in A549 cells, HepG2 cells, MCF7 cells, SGC-7901 cells. Observed molecular weight by Western-blot: 28-31; 66-70 kDa

Tested applications :
ELISA, IF, IHC, WB

Species reactivity :
Human, Mouse; other species not tested.

Alternative names :
CL 6 antibody; INSIG 1 antibody; INSIG1 antibody; insulin induced gene 1 antibody; Insulin induced gene 1 protein antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of INSIG1 recombinant protein (Accession Number: NM_001346592). Purification method: Antigen affinity purified.

Clonality :
Polyclonal

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200IF: 1:20-1:200

Background :
INSIG1 represents insulin induced gene 1

References :
Dang R, Jiang P, Cai H. Vitamin D deficiency exacerbates atypical antipsychotic-induced metabolic side effects in rats: involvement of the INSIG/SREBP pathway. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 25(8):1239-47. 2015. Cai HL, Tan QY, Jiang P. A potential mechanism underlying atypical antipsychotics-induced lipid disturbances. Translational psychiatry. 5:e661. 2015.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: Gardos- Channel