Name :
Integrin alpha-1 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Integrin alpha-1 Rabbit Polyclonal antibody. Positive IHC detected in human tonsillitis tissue. Positive FC detected in HeLa cells. Positive WB detected in HepG2 cells, SMMC-7721 cells. Observed molecular weight by Western-blot: 180 kDa
Tested applications :
ELISA, WB, IHC, FC
Species reactivity :
Human; other species not tested.
Alternative names :
CD49a antibody; Integrin alpha 1 antibody; integrin antibody; alpha 1 antibody; ITGA1 antibody; Laminin and collagen receptor antibody; VLA 1 antibody; VLA1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of Integrin alpha-1 recombinant protein (Accession Number: NM_181501). Purification method: Antigen Affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200
Background :
The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID:19118207). Integrin alpha-1 (ITGA1, CD49a) combines with the beta 1 subunit (ITGB1, CD29) to form a cell-surface receptor for collagen and laminin. This receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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