Name :
Integrin alpha-3 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Integrin alpha-3 Mouse Monoclonal antibody. Positive WB detected in PC-3 cells. Positive FC detected in A549 cells. Observed molecular weight by Western-blot: 120 kDa
Tested applications :
ELISA, WB, FC
Species reactivity :
Human; other species not tested.
Alternative names :
CD49C antibody; FLJ34631 antibody; FLJ34704 antibody; FRP 2 antibody; Galactoprotein B3 antibody; GAP B3 antibody; GAPB3 antibody; Integrin alpha 3 antibody; ITGA3 antibody; MSK18 antibody; VCA 2 antibody; VL3A antibody; VLA 3 subunit alpha antibody; VLA3a antibody
Immunogen :
Isotype :
Mouse IgG2a
Preparation :
This antibody was obtained by immunization of Integrin alpha-3 recombinant protein (Accession Number: NM_002204). Purification method: Protein A purified.
Clonality :
Monoclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000
Background :
ITGA3, also named as MSK18, CD49c, GAPB3 and FRP-2, belongs to the integrin alpha chain family. It is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. ITGA3 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. ITGA3 is highly concentrated in epithelial cells where it strongly adheres to Laminin-5 and Laminin-5 induced rapid adhesion can be blocked by antibodies against the alpha-3 integrin subunit. It can be cleaved into heavy chain(840aa) and light chain(176aa). This antibody can recognize the heavy chain.
References :
Ren Y, Hao P, Law SK, Sze SK. Hypoxia-induced changes to integrin α 3 glycosylation facilitate invasion in epidermoid carcinoma cell line A431. Molecular & cellular proteomics : MCP. 13(11):3126-37. 2014.
Related websites: https://www.medchemexpress.com/antibodies.html
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