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Name :
Integrin alpha 6X1A-Specific antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
Integrin alpha 6X1A-Specific Rabbit Polyclonal antibody. Positive WB detected in mouse spleen tissue, mouse colon tissue. Observed molecular weight by Western-blot: 100 kDa, 150 kDa

Tested applications :
ELISA, WB

Species reactivity :
Human, Mouse; other species not tested.

Alternative names :
ITGA6 antibody; CD49f antibody; FLJ18737 antibody; Integrin alpha 6 antibody; ITGA6B antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of Peptide (Accession Number: NM_000210). Purification method: Antigen affinity purified.

Clonality :
Polyclonal

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:200-1:1000

Background :
ITGA6, also named as CD49f and VLA-6, belongs to the integrin alpha chain family. It is a receptor for laminin on platelets. ITGA6 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. Defects in ITGA6 are a cause of epidermolysis bullosa letalis with pyloric atresia (EB-PA) which also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. The antibody is specific to isoform Alpha-6X1A, isoform Alpha-6X2A, isoform Alpha-6X1X2A isoform7 and isoform9 of ITGA6.

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: Gardos- Channel