Name :
INVS Polyclonal Antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Polyclonal antibody to INVS
Tested applications :
WB
Species reactivity :
Human, Mouse
Alternative names :
INVS antibody; INV antibody; NPH2 antibody; NPHP2 antibody; inversin antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human INVS (NP_055240.2).
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage instructions :
Store at -20℃. Avoid freeze / thaw cycles.
Applications :
WB 1:500 – 1:2000
Background :
Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity).
References :
Related websites: https://www.medchemexpress.com/antibodies.html
Popular product recommendations:
Secukinumab
Certolizumab pegol
Myogenin Antibody: Myogenin Antibody is an unconjugated, approximately 25 kDa, rabbit-derived, anti-Myogenin polyclonal antibody. Myogenin Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in (predicted) human, mouse, rat, pig, cow, horse, rabbit, sheep background without labeling.
