Name :
ITM2C Polyclonal Antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Polyclonal antibody to ITM2C
Tested applications :
WB
Species reactivity :
Mouse, Rat
Alternative names :
ITM2C antibody; BRI3 antibody; BRICD2C antibody; E25 antibody; E25C antibody; ITM3 antibody; integral membrane protein 2C antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ITM2C (NP_001012532.1).
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage instructions :
Store at -20℃. Avoid freeze / thaw cycles.
Applications :
WB 1:500 – 1:2000
Background :
Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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