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Name :
ITPR1-specific antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
ITPR1-specific Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue, mouse liver tissue. Positive FC detected in HepG2 cells. Positive IHC detected in human testis tissue. Observed molecular weight by Western-blot: 290-300 kDa

Tested applications :
ELISA, WB, IHC, FC

Species reactivity :
Human,Mouse,Rat; other species not tested.

Alternative names :
INSP3R1 antibody; IP3 receptor isoform 1 antibody; IP3R antibody; IP3R 1 antibody; IP3R1 antibody; ITPR1 antibody; SCA15 antibody; SCA16 antibody; Type 1 InsP3 receptor antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of Peptide (Accession Number: NM_001099952). Purification method: Antigen affinity purified.

Clonality :
Polyclonal

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200

Background :
ITPR1, also named as INSP3R1 and IP3R, belongs to the InsP3 receptor family. It is a receptor for inositol 1,4,5-trisphosphate which is a second messenger that mediates the release of intracellular calcium. Defects in ITPR1 are the cause of spinocerebellar ataxia type 15 (SCA15). The antibody has no cross reaction with ITPR2 and ITPR3.

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: Gardos- Channel