Name :
JMY antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
JMY Rabbit Polyclonal antibody. Positive IF detected in HeLa cells. Positive IHC detected in human colon cancer tissue, human brain tissue. Positive IP detected in Jurkat cells. Positive WB detected in Jurkat cells, HeLa cells. Observed molecular weight by Western-blot: 111 kDa
Tested applications :
ELISA, WB, IHC, IF, IP
Species reactivity :
Human, Mouse, Rat; other species not tested.
Alternative names :
FLJ37870 antibody; JMY antibody; WHDC1L3 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of JMY recombinant protein (Accession Number: BC130624). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:200-1:2000IHC: 1:20-1:200IF: 1:10-1:100
Background :
Junction mediating and regulatory protein（JMY) is a 988 amino acid protein, which contains one WH2 domain and belongs to the JMY family. IIn nucleus, JMY acts both a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics in response to cellular stress. In cytoplasm, JMY acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Due to alternative splicing, several isoforms of JMY are produced, and these various isoforms have different influencing affects on p53 activation, with some isoforms markedly enhancing p53 responses compared to the other splicing variants.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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