Name :
JTV1 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
JTV1 Rabbit Polyclonal antibody. Positive IHC detected in human testis tissue, human cerebellum tissue, human kidney tissue. Positive IF detected in Hela cells, HepG2 cells. Positive IP detected in HeLa cells. Positive WB detected in HeLa cells, HepG2 cells, K-562 cells, L02 cells, mouse liver tissue, NIH/3T3 cells, rat liver tissue. Observed molecular weight by Western-blot: 36 kDa
Tested applications :
ELISA, WB, IF, IHC, IP
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
AIMP2 antibody; JTV1 antibody; JTV1 gene antibody; P38 antibody; PRO0992 antibody; Protein JTV 1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of JTV1 recombinant protein (Accession Number: NM_006303). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:500-1:5000IHC: 1:20-1:200IF: 1:10-1:100
Background :
JTV1, also named p38, AIMP2, was first knew as a factor associated with macromolecular protein complex, which consists several different aminoacyl-tRNA synthetases. JTV1 is a scaffold protein required for the assembly and stability of the multi-tRNA synthetase complex. JTV1 could act as a mediator of TGF-beta signaling and its functional importance in the control of MYC during lung differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. This is a rabbit polyclonal antibody raised against full-length of JTV1.
References :
Choo YS, Tang C, Zhang Z. Critical role of PINK1 in regulating Parkin protein levels in vivo. Archives of neurology. 68(5):684-5. 2011. Wong E, Bejarano E, Rakshit M. Molecular determinants of selective clearance of protein inclusions by autophagy. Nature communications. 3:1240. 2012. Gulati P, Cheung MK, Antrobus R. Role for the obesity-related FTO gene in the cellular sensing of amino acids. Proceedings of the National Academy of Sciences of the United States of America. 110(7):2557-62. 2013. Ma J, Chen M, Xia SK. Prostaglandin E2 promotes liver cancer cell growth by the upregulation of FUSE-binding protein 1 expression. International journal of oncology. 42(3):1093-104. 2013. Lee Y, Karuppagounder SS, Shin JH. Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss. Nature neuroscience. 16(10):1392-400. 2013. Ko HS, Lee Y, Shin JH. Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin’s ubiquitination and protective function. Proceedings of the National Academy of Sciences of the United States of America. 107(38):16691-6. 2010. Turanov AA, Shchedrina VA, Everley RA. Selenoprotein S is involved in maintenance and transport of multiprotein complexes. The Biochemical journal. 462(3):555-65. 2014. Jäger S, Cimermancic P, Gulbahce N. Global landscape of HIV-human protein complexes. Nature. 481(7381):365-70. 2012.
Related websites: https://www.medchemexpress.com/antibodies.html
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