Name :
Kallikrein 1 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Kallikrein 1 Rabbit Polyclonal antibody. Positive IHC detected in human pancreas cancer tissue. Positive IP detected in BxPC-3 cells. Positive WB detected in A375 cells, BxPC-3 cells. Observed molecular weight by Western-blot: 45-50kd
Tested applications :
ELISA, WB, IHC, IP
Species reactivity :
Human; other species not tested.
Alternative names :
hK1 antibody; kallikrein 1 antibody; KLK1 antibody; Klk6 antibody; KLKR antibody; Tissue kallikrein antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of Kallikrein 1 recombinant protein (Accession Number: NM_002257). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:200-1:2000IHC: 1:20-1:200
Background :
KLK1 (tissue kallikrein 1) is a member of the tissue kallikrein family of serine proteases and is the primary kinin-generating enzyme in human airways. It is involved in the control of ionic transport in the renal tubule, an action that may not be kinin-mediated. This protein has 2 isoforms produced by alternative splicing.
References :
Cerutti JM, Oler G, Delcelo R. PVALB, a new Hürthle adenoma diagnostic marker identified through gene expression. The Journal of clinical endocrinology and metabolism. 96(1):E151-60. 2011. Yu HZ, Xie LD, Zhu PL, Xu CS, Wang HJ. Human tissue kallikrein 1 gene delivery inhibits PDGF-BB-induced vascular smooth muscle cells proliferation and upregulates the expressions of p27Kip1 and p2lCip1. Molecular and cellular biochemistry. 360(1-2):363-71. 2012. Li Y, Raman I, Du Y. Kallikrein transduced mesenchymal stem cells protect against anti-GBM disease and lupus nephritis by ameliorating inflammation and oxidative stress. PloS one. 8(7):e67790. 2013.
Related websites: https://www.medchemexpress.com/antibodies.html
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