Name :
KAT5 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
KAT5 Rabbit Polyclonal antibody. Positive IHC detected in human prostate cancer tissue. Positive WB detected in PC-3 cells, HeLa cells, Jurkat cells, mouse liver tissue, rat liver tissue. Observed molecular weight by Western-blot: 55-60 kDa
Tested applications :
ELISA, WB, IHC
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
60 kDa Tat interactive protein antibody; cPLA(2) interacting protein antibody; cPLA2 antibody; ESA1 antibody; Histone acetyltransferase KAT5 antibody; HIV 1 Tat interactive protein antibody; HTATIP antibody; HTATIP1 antibody; K(lysine) acetyltransferase 5 antibody; KAT5 antibody; Lysine acetyltransferase 5 antibody; PLIP antibody; TIP antibody; TIP60 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of KAT5 recombinant protein (Accession Number: NM_182709). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200
Background :
KAT5 belongs to the MYST protein family that contains atypical zinc finger and histone acetyltransferase domains. Also, KAT5 contains a chromodomain. KAT5 is a catalytic subunit of the NuA4 histone acetyltransferase complex. The NuA4 HAT complex plays a role in transcriptional activation of select genes mainly by acetylation of nucleosomal histone H4 and H2A, which influence nucleosome-DNA interaction and promotes interaction of the modified histones with other proteins that could regulate transcription positively. This complex also involves in the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, DNA repair and apoptosis.
References :
Obri A, Ouararhni K, Papin C. ANP32E is a histone chaperone that removes H2A.Z from chromatin. Nature. 505(7485):648-53. 2014. Yu H, Diao H, Wang C. Acetylproteomic analysis reveals functional implications of lysine acetylation in human spermatozoa (sperm). Molecular & cellular proteomics : MCP. 14(4):1009-23. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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