Name :
KHDRBS3 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
KHDRBS3 Rabbit Polyclonal antibody. Positive WB detected in HepG2 cells, A549 cells, human brain tissue, mouse brain tissue. Positive IHC detected in human gliomas tissue. Observed molecular weight by Western-blot: 55 kDa
Tested applications :
ELISA, WB, IHC
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
Etle antibody; etoile antibody; KHDRBS3 antibody; RNA binding protein T Star antibody; SALP antibody; Sam68 like mammalian protein 2 antibody; SLM 2 antibody; SLM2 antibody; T STAR antibody; TSTAR antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of KHDRBS3 recombinant protein (Accession Number: NM_006558). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200
Background :
KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3, SLM2) is a RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion (15901763). May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1 gene expression (11741900).Ubiquitous with higher expression in testis, skeletal muscle and brain. Expressed in the kidney only in podocytes, the glomerular epithelial cells of the kidney. Strongly expressed after meiosis.This antibody is a rabbit polyclonal antibody raised against a full-length human KHDRBS3 protein.The observed molecular weight of KHDRBS is about 55kd.
References :
Neumann M, Valori CF, Ansorge O. Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations. Acta neuropathologica. 124(5):705-16. 2012. Ehrmann I, Dalgliesh C, Liu Y. The tissue-specific RNA binding protein T-STAR controls regional splicing patterns of neurexin pre-mRNAs in the brain. PLoS genetics. 9(4):e1003474. 2013.
Related websites: https://www.medchemexpress.com/antibodies.html
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