Name :
KIF22 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
KIF22 Rabbit Polyclonal antibody. Positive IHC detected in human cervical cancer tissue. Positive IP detected in HeLa cells. Positive WB detected in human heart tissue. Observed molecular weight by Western-blot: 73 kDa
Tested applications :
ELISA, WB, IHC, IP
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
KID antibody; KIF22 antibody; kinesin family member 22 antibody; Kinesin like protein 4 antibody; Kinesin like protein KIF22 antibody; KNSL4 antibody; OBP antibody; OBP 1 antibody; OBP 2 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of KIF22 recombinant protein (Accession Number: NM_007317). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:200-1:1000IHC: 1:20-1:200
Background :
KIF22, also known as KID (kinesin-like DNA-binding protein), is a kinesin-like DNA-binding protein known to be involved in chromosome movement during mitosis. KIF22 is a nuclear protein regulated by SIAH-1, whose level fluctuate in a cell cycle-dependent manner, increasing during pre-mitotic phases and greatly decreasing during mitosis. KIF22 localizes to the nucleus of the interphase cells upon entry into mitosis and displays some punctate cytoplasmic staining. Defects in KIF22 are the cause of spondyloepimetaphyseal dysplasia with joint laxity, type 2 (SEMDJL2).
References :
Yan GR, Zou FY, Dang BL. Genistein-induced mitotic arrest of gastric cancer cells by downregulating KIF20A, a proteomics study. Proteomics. 12(14):2391-9. 2012.
Related websites: https://www.medchemexpress.com/antibodies.html
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