Name :
KRAP, SSFA2 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
KRAP, SSFA2 Rabbit Polyclonal antibody. Positive IHC detected in human pancreas tissue. Positive IP detected in mouse testis tissue. Positive WB detected in rat testis tissue. Observed molecular weight by Western-blot: 180 kDa
Tested applications :
ELISA, WB, IP, IHC
Species reactivity :
Human, Rat; other species not tested.
Alternative names :
Cleavage signal 1 protein antibody; CS 1 antibody; CS1 antibody; DKFZp313O1039 antibody; DKFZp779G0129 antibody; FLJ45996 antibody; KIAA1927 antibody; KRAP antibody; SPAG13 antibody; sperm specific antigen 2 antibody; SSFA2 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of KRAP, SSFA2 recombinant protein (Accession Number: NM_006751). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:200-1:2000IHC: 1:20-1:200
Background :
KRAP (Ki-ras-induced actin-interacting protein), also known as SSFA2, CS1 or SPAG13, is a 1,259 amino acid cytoplasmic protein associated with filamentous-actin (F-actin). KRAP is strongly expressed in pancreas and testis. It is also present in colon cancer cell lines, and the expression is up-regulated by activated K-Ras. KRAP-deficient (KO) mice display decreased adiposity and improved glucose metabolism, implicating KRAP as a potential target for the prevention or treatment of obesity and related diseases. KRAP has also been suggested to be a potential target for cancer. This antibody recognizes endogenous KRAP, which migrates with an apparent molecular mass of 180 kDa in SDS-PAGE. (PMID: 14673706; 21501587; 21873152)
References :
Dingli F, Parys JB, Loew D, Saule S, Mery L. Vimentin and the K-Ras-induced actin-binding protein control inositol-(1,4,5)-trisphosphate receptor redistribution during MDCK cell differentiation. Journal of cell science. 125(Pt 22):5428-40. 2012.
Related websites: https://www.medchemexpress.com/antibodies.html
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